Overview
| Specificity: |
This product is specific for Abatacept. |
| Host Species: |
Mouse |
| Immunogen: |
Abatacept |
| Conjugate: |
Unconjugated |
Applications
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
| Application |
| Sandwich ELISA |
| ELISA |
| Recommended Usage |
| 0.5-2 μg/ml |
| 0.01-1 µg/ml |
Properties
| Form: |
Lyophilized
|
| Storage Buffer: |
Lyophilized with PBS, pH 7.2, containing 0.02% sodium azide.
|
| Reconstitution: |
Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.
|
| Storage Instructions: |
The lyophilized product remains stable for up to 1 year at -20 °C from the date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below. Avoid repeated freezing and thawing cycles.
|
| Purification: |
Protein A affinity column
|
| Isotype: |
Mouse IgG1, κ
|
| Clonality: |
Monoclonal
|
| Clone ID: |
CT.F3
|
| Note: |
GenScript can customize this product per customer's request including product size, buffer components, etc.
|
Background
| Target Background: |
Abatacept, also known as Orencia, is a medication utilized for the treatment of autoimmune diseases like rheumatoid arthritis. By interfering with the immune activity of T cells, Abatacept helps in managing these conditions. It is a fusion protein that combines the extracellular domain of CTLA-4 with the Fc region of the immunoglobulin IgG1. Abatacept is a medication that is utilized as a second-line treatment for adults with moderate to severe rheumatoid arthritis (RA). For individuals whose RA is severe and rapidly progressing, it can be used as a first-line treatment. Furthermore, Abatacept is also prescribed for the treatment of psoriatic arthritis and juvenile idiopathic arthritis. |
| Synonyms: |
Abatacept, Orencia, Anti-CTLA-4 antibody, CTLA4lg, BMS-188667, CTL A4-Ig B7 Inhibitor, RG2077 |
Caution
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
